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Movie 2.

The RhoGAP function of DLC1 inhibits basal Rho signaling. Live TIRF microscopy recordings of imaged HUVECs stimulated with thrombin and expressing the Rho biosensor dT-2xrGBD in control cells, or in GFP-DLC1 or GFP-DLC1-R677E cells.

DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover

Aukie Hooglugt, Miesje M. van der Stoel, Apeksha Shapeti, Beau F. Neep, Annett de Haan, Hans van Oosterwyck, Reinier A. Boon, and Stephan Huveneers

J Cell Sci 2024. 137:None-None; doi: 10.1242/jcs.261687

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