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Movie 4.

Thrombin restores cell adhesion in DLC1-overexpressing HUVECs. Live TIRF microscopy recordings of imaged HUVECs transduced with GFP (Control), GFP-DLC1 or GFP-DLC1-R677E and mCherry-paxillin stimulated with thrombin.

DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover

Aukie Hooglugt, Miesje M. van der Stoel, Apeksha Shapeti, Beau F. Neep, Annett de Haan, Hans van Oosterwyck, Reinier A. Boon, and Stephan Huveneers

J Cell Sci 2024. 137:None-None; doi: 10.1242/jcs.261687