Movie 1.
Time-lapse imaging after harmine exposure by observing Coilin-mRuby2 transiently expressed in HeLa cells. Images were acquired every 2 min for 3 hrs after harmine exposure. After 90 min of harmine treatment Coilin rapidly disappears from Cajal bodies and accumulates in PNC.
Dissecting the role of SMN multimerization in its dissociation from the Cajal body using harmine as a tool compound
J Cell Sci 2024. 137:None-None; doi: 10.1242/jcs.261834