Movie 1.

Macrophages effectively taking up protocells at the wound site. Time-lapse confocal movie showing uptake of protocells (green dots) by wound-recruited macrophages (red cells) in a wounded Tg(mpeg1:mCherry) larva at 0.5 hours post-wounding after systemic protocell injection. Note that macrophages can take up protocells accumulated at the damaged intersegmental vessel and those that leaked from this vessel towards the wound site.

Reprogramming macrophages with R848-loaded artificial protocells to modulate skin and skeletal wound healing

Paco López-Cuevas, Tiah C. L. Oates, Qiao Tong, Lucy M. McGowan, Stephen J. Cross, Can Xu, Yu Zhao, Zhuping Yin, Ashley M. Toye, Asme Boussahel, Chrissy L. Hammond, Stephen Mann, and Paul Martin

J Cell Sci 2024. 137:None-None; doi: 10.1242/jcs.262202