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Movie 1

Tube formation is driven by gel contraction. 24h time-lapse movie in .mp4 format showing that collagen gels contract over time forcing organoids into alignment and close proximity.

Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels

Norman Sachs, Yoshiyuki Tsukamoto, Pekka Kujala, Peter J. Peters, and Hans Clevers

Development 2017. 144:1107-1112; doi: 10.1242/dev.143933