Movie 8.

EC1.45-active cells appear to contribute to Meckel's cartilage formation by Cremediated lineage tracing. Time-lapse movie of confocal images (maximum intensity projections) over 12 hours from 2 dpf of representative embryo 1 (see Fig. S7Bi), which exhibited an AmCyan to ZsYellow switch in the frontonasal craniofacial region at 1 dpf. ZsYellow signal was observed adjacent to Meckel's cartilage at 2 dpf, with emergence of a ZsYellow-positive, sox10-positive cell within Meckel's cartilage observed at around 60 hpf (white arrow). Scale bar 20 μm.

Neanderthal-derived variants increase SOX9 enhancer activity in craniofacial progenitors that shape jaw development

Kirsty Uttley, Hannah J. Jüllig, Carlo De Angelis, Julia M. T. Auer, Ewa Ozga, Hemant Bengani, and Hannah K. Long

Development 2025. 152:None-None; doi: 10.1242/dev.204779