Movie 2.

Simulation Movies with Cadherin 2 Repression of Integrin α5. Movies from the DEM simulations with parameters selected to represent the (A) integrin a5 mutant, (B) wild type, (C) integrin α5; cadherin 2 double mutant, and (D) cadherin 2 mutant, incorporating an additional energy term for enhanced activation of integrin α5 in the absence of Cadherin 2. Cells are shown in magenta, with the tissue boundary in green. Red lines represent cell-ECM bonds via additional activation of integrin α5.