Movie 2.
Ectopic network in a T-DM1-injected brain. 3D animation followed by single planes from dorsal to ventral of light sheet microscopy images of a mrc1a:mCitrine-positive, cleared T-DM1-injected brain lacking BLECs, but highlighting the ectopic vessel network by immunostaining against GFP. The network is present in the leptomeninges. Note that the dorsal forebrain is not populated by the network.
Loss of meningeal lymphatic endothelial cells results in formation of a newly forming vascular network with scavenging function
Development 2026. 153:None-None; doi: 10.1242/dev.204988