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Movie 1.

Live imaging of atp6v1f-/- mutant neuromast hair cells expressing Tg(myo6b:tdtomato) at 4 dpf. Arrowhead follows a single hair cell that swells over time. Note that fluorescent tdTomato protein accumulates into aggregates that are reminiscent of LC3b-GFP aggregates that mark autophagosomes (see Fig. 3). Time stamp=hours:minutes

Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts

Peu Santra, and Jeffrey D. Amack

Disease Models and Mechanisms 2021. 14:None-None; doi: 10.1242/dmm.048997