Movie S8

The ADAP-120 and ADAP-130 isoforms both enter TCR-induced SLP-76 microclusters and lamellipodia (ADAP-120 movie). J14.SY cells were transiently transfected with a 3xFlag.TRT.ADAP expression vector for ADAP-120. ADAP is shown in the left panel and in red in the merge, SLP-76 in the middle panel and in green in the merge.

ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters

Juliana B. Lewis, Frank A. Scangarello, Joanne M. Murphy, Keith P. Eidell, Michelle O. Sodipo, Michael J. Ophir, Ryan Sargeant, Maria-Cristina Seminario, and Stephen C. Bunnell

J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.215517

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