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Movie 17

Live imaging video file (Movie 16) and serial tomogram and 3D model (Movie 17) corresponding to Fig. 4C and Fig. 4H, respectively. Movie 17 shows an inner autophagosome and multiple ER membranes surrounding it, suggesting it is an immature AV. Of note, an additional concentrical structure exhibiting a dense core is also exhibited.

Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells

Claudio Bussi, Javier M. Peralta Ramos, Daniela S. Arroyo, Jose I. Gallea, Paolo Ronchi, Androniki Kolovou, Ji M. Wang, Oliver Florey, Maria S. Celej, Yannick Schwab, Nicholas T. Ktistakis, and Pablo Iribarren

J Cell Sci 2018. 131:None-None; doi: 10.1242/jcs.226241