Movie 2.
Integrin internalisation in B16-F1 Cyri-b KO cells rescued with CYRI-B p17-GFP. Live imaging of B16-F1 Cyri-b KO cells rescued with CYRI-B-p17-GFP (Cyan) and β1-integrinmCherry (Magenta). Yellow arrowheads highlight β1-integrin positive structures surrounded by CYRI-B. 1 image acquired every 10 seconds and playback at 7 frames per second. Scale bar represents 10 μm.
CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge
J Cell Sci 2025. 138:None-None; doi: 10.1242/jcs.263646