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Movie 1.

Oleate uptake is fast and rapidly distributed in the ER in MDA-MB-231 AA cells. MDA-MB-231 AA cells were perfused first with pH buffered saline, then with saline buffer including 5 μM TopFluor oleate at 37°C without CO2. Imaged with live with confocal microscopy.

Tumor acidosis supports cancer cell lipid uptake via a rapid transporter-independent mechanism

Marc Severin, Rikke K. Hansen, Michala G. Rolver, Tove Hels, Kenji Maeda, Luis A. Pardo, and Stine F. Pedersen

J Cell Sci 2025. 138:None-None; doi: 10.1242/jcs.263688