Movie 1.
Oleate uptake is fast and rapidly distributed in the ER in MDA-MB-231 AA cells. MDA-MB-231 AA cells were perfused first with pH buffered saline, then with saline buffer including 5 μM TopFluor oleate at 37°C without CO2. Imaged with live with confocal microscopy.
Tumor acidosis supports cancer cell lipid uptake via a rapid transporter-independent mechanism
J Cell Sci 2025. 138:None-None; doi: 10.1242/jcs.263688