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Movie 5.

Class I PAK kinase inhibition drives the formation of dramatic travelling actin waves in B16F1 cells. Widefield fluorescence microscopy of a B16F1 cell, transiently transfected to express mEGFP, responding to the addition of 10 μM G5555. Addition of the drug occurs after 60 minutes, and the point of addition is indicated in the movie. Stills from this movie make up Fig. 3E.

A role for class I p21-activated kinases in the regulation of the excitability of the actin cytoskeleton

Joe J. Tyler, Anthony Davidson, Megan E. Poxon, Montserrat Llanses Martinez, Pete Hume, Jason S. King, and Vassilis Koronakis

J Cell Sci 2025. 138:None-None; doi: 10.1242/jcs.263763