Movie 3.
Retrograde movements of 80 small solute molecules originating in a lysosome. Each pore connecting two organelles allows solute exchange by diffusion to reach concentration equilibrium before closure of the pore. Eventual merger of the macropinosome into the lysosome limits rates of solute backflow out of the cell.
Macropinocytosis facilitates amino acid acquisition from extracellular fluid to support cell proliferation in macrophages
J Cell Sci 2026. 139:None-None; doi: 10.1242/jcs.264398