Movie 8.

MRTF-A reexpression restores morphology, motility, and proliferation. Mrtfa-/-Mrtfbfl/fl DoxMRTF-A cells were treated as in Fig. 5E and analysed by Phasefocus livecyte microscopy at day 12 for 40h at 2 images/h. Phase contrast images. 4OHT-treated cells at day 12 treated with Dox 1h prior to imaging. Velocity of the untreated cells decreases at later times as cells become confluent, which was not reached by the Dox-treated cells (compare Movies 3,5).

MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

Julie C. Nielsen, Maria Benito-Jardon, Noel Christo Petrela, Jessica Diring, Sofie Bellamy, and Richard Treisman

J Cell Sci 2024. 138:None-None; doi: 10.1242/jcs.264444